Cell Biology

Sterling Hall of Medicine C207, 203.737.5603
http://cellbiology.yale.edu
M.S., M.Phil., Ph.D.

Chair
James Rothman

Director of Graduate Studies
Karin Reinisch (SHM C214a, 203.785.6469, karin.reinisch@yale.edu)

Professors Joerg Bewersdorf, Christopher Burd, David Calderwood (Pharmacology), Michael Caplan (Cellular and Molecular Physiology), Daniel Colón-Ramos, Lynn Cooley (Genetics), Peter Cresswell (Immunobiology), Pietro De Camilli, Jorge Galán (Microbial Pathogenesis), Fred Gorelick, Valentina Greco (Genetics), Carl Hashimoto (Emeritus), Diane Krause (Laboratory Medicine), Thomas Lentz (Emeritus), Haifan Lin, Jun Liu (Microbial Pathogenesis), Vincent Marchesi (Pathology), Mark Mooseker (Molecular, Cellular, and Developmental Biology), Michael Nathanson (Internal Medicine/Digestive Diseases), Karla Neugebauer (Molecular Biophysics and Biochemistry), Karin Reinisch, James Rothman, Martin Schwartz (Internal Medicine/Cardiology), Derek Toomre, Felix Weiland (Adjunct), Sandra Wolin (Emerita)

Associate Professors Julien Berro (Molecular Biophysics and Biochemistry), Jonathan Bogan (Internal Medicine/Endocrinology), Shawn Ferguson, Shangqin Guo, Megan King, Chenxiang Lin, Patrick Lusk, Malaiyalam Mariappan, Thomas Melia, Christian Schlieker (Molecular Biophysics and Biochemistry), Julia von Blume, Min Wu, Yongli Zhang

Assistant Professors David Baddeley (Adjunct), Kallol Gupta, Xiaolei Su, Peter Takizawa, Siyuan Wang (Genetics), Shaul Yogev (Neuroscience)

Fields of Study

Fields include membrane traffic and protein sorting, organelle biogenesis, epithelial cell polarity, membrane function in the nervous system (synapse formation and function), neural circuit development, cell biology of protozoan parasites and of pathogen/host interactions, cell biology of the immune response, mRNA biogenesis and localization, RNA folding, non-coding RNAs, stem cells, the cytoskeleton, nuclear structure and dynamics, DNA nanostructures, cellular signaling and motility, cytokinesis. Approaches to these topics include biochemistry, biophysics, molecular biology, crystallography, and single-particle electron microscopy; bacterial, yeast, Drosophila, C. elegans, and mouse genetics; immunocytochemistry and electron microscopy and tomography; live cell and super-resolution imaging.

To enter the Ph.D. program, students apply to an interest-based track, usually the Molecular Cell Biology, Genetics, and Development (MCGD) track or the Biochemistry, Quantitative Biology, Biophysics, and Structural Biology (BQBS) track, within the interdepartmental graduate program in Biological and Biomedical Sciences (BBS), https://medicine.yale.edu/bbs.

Special Requirements for the Ph.D. Degree

Students are required to take at least five graduate-level courses. No specific curriculum of courses is required, but CBIO 602 (Molecular Cell Biology) is recommended for all students to attain a solid foundation in molecular cell biology. Also recommended is a seminar course, such as CBIO 603 (Seminar in Molecular Cell Biology), in which students can develop the skill for critical analysis of research papers. Students design their own curriculum of courses to meet individual interests and needs, in consultation with the director of graduate studies. During the first year, students participate in three laboratory rotations. In the second year, a committee of faculty members determines whether each student is qualified to continue in the Ph.D. program. There is an oral qualifying examination by the end of the third term. In order to be admitted to candidacy, students must have met the Graduate School Honors requirement, maintained a High Pass average in course work, passed the qualifying examination, submitted an approved prospectus, and received a positive evaluation of their laboratory work from the thesis committee. All students are required to present a talk at the departmental progress report series each year after passing the qualifying exam. The remaining degree requirements include completion of the dissertation project, submission for publication of at least one first-author paper to a peer-reviewed journal describing the dissertation research, the writing of the dissertation and its oral defense, the formal submission of copies of the written dissertation to the Graduate School, and the deposit of an additional copy with the department.

An important aspect of graduate training in cell biology is the acquisition of teaching skills through participation in courses appropriate for the student’s scientific interests. These opportunities can be drawn from a diverse menu of lecture, laboratory, and seminar courses given at the undergraduate, graduate, and medical school levels. Ph.D. students are required to participate in two terms (or the equivalent) of teaching. Students are not expected to teach during their first year.

In addition to all other requirements, students must successfully complete CBIO 900 and CBIO 901 (Research Skills and Ethics I and II) prior to the end of their first year of study. In their fourth year of study, all students must successfully complete B&BS 503 (RCR Refresher for Senior BBS Students).

M.D./Ph.D. Students

M.D./Ph.D. students are required to take a total of five graduate-level courses for a grade, including the CBIO 501/CBIO 502 sequence (Molecules to Systems), CBIO 602 (Molecular Cell Biology), and a seminar course that involves the reading and class discussion of research papers. The remaining courses can be in areas such as Genetics, Neuroscience, Immunology, Microbiology, Pharmacology, and Physiology. Students must meet the Graduate School requirement of a grade of Honors in two courses, if necessary taking additional courses beyond the five required in the department to fulfill this requirement. Students must also maintain an average grade of High Pass in all courses. One term of teaching is required.

Master’s Degrees

M.Phil. Requirements for the M.Phil. degree are the same as for admission to candidacy (see above).

M.S. This degree is normally granted only to students who are withdrawing from the Ph.D. program. To be eligible for the degree, a student must have completed at least five graduate-level term courses at Yale, including CBIO 602 (Molecular Cell Biology) and a seminar course, with a grade of Pass and at least one grade of Honors or three of High Pass. In addition to these five courses, the student must have received a Satisfactory grade in the following five courses: CBIO 900 (Research Skills and Ethics I), CBIO 901 (Research Skills and Ethics II), CBIO 911 (First Laboratory Rotation), CBIO 912 (Second Laboratory Rotation), and CBIO 913 (Third Laboratory Rotation). Students who are eligible for or who have already received the M.Phil. will not be awarded the M.S.


Prospective applicants are encouraged to visit the BBS website (https://medicine.yale.edu/bbs), MCGD and BQBS tracks. Program materials are available upon request to the Director of Graduate Studies, Department of Cell Biology, Yale University, PO Box 208002, New Haven CT 06520-8002.

Courses

CBIO 501a and CBIO 502b, Molecules to SystemsPeter Takizawa

This full-year course (CBIO 501/CBIO 502) is designed to provide medical students with a current and comprehensive review of biologic structure and function at the cellular, tissue, and organ system levels. Areas covered include structure and organization of cells; regulation of the cell cycle and mitosis; protein biosynthesis and membrane targeting; cell motility and the cytoskeleton; signal transduction; cell adhesion; cell and tissue organization of organ systems. Clinical correlation sessions, which illustrate the contributions of cell biology to specific medical problems, are interspersed in the lecture schedule. Histophysiology laboratories provide practical experience with an understanding of exploring cell and tissue structure. The course is offered only to M.D. and M.D./Ph.D. students.
HTBA

CBIO 600a and CBIO 601b, Science at the Frontiers of MedicineStaff

This full-year graduate seminar (CBIO 600/CBIO 601) for first-year M.D./Ph.D. students—an elective course for M.D. students—matches the progression of topics in the eighteen-month preclinical medical school curriculum and emphasizes the connections between basic and clinical science, human physiology, and disease. It is directed by M.D./Ph.D. program faculty, and many class discussions are led by expert Yale School of Medicine faculty members who select the papers to be read. Students explore scientific topics in depth, learn about cutting-edge research, and improve their presentation skills. The curriculum provides a framework for critically reading and analyzing papers drawn broadly from the biomedical sciences; this breadth of knowledge is also leveraged in team-based exercises that promote peer-to-peer teaching and learning. Enrollment limited to students who have taken or are currently taking CBIO 501/CBIO 502.
Th 4:30pm-6pm

CBIO 602a / MB&B 602a / MCDB 602a, Molecular Cell BiologyThomas Melia, Martin Schwartz, Shawn Ferguson, Malaiyalam Mariappan, Nadya Dimitrova, Xiaolei Su, Valerie Horsley, Megan King, Patrick Lusk, Christopher Burd, David Breslow, Shaul Yogev, and Min Wu

A comprehensive introduction to the molecular and mechanistic aspects of cell biology for graduate students in all programs. Emphasizes fundamental issues of cellular organization, regulation, biogenesis, and function at the molecular level. Prerequisites: none, but some knowledge of basic cell biology and biochemistry is assumed. Students who have not taken courses in these areas can prepare by reading relevant sections in basic molecular cell biology texts. We recommend Pollard et al., Cell Biology (3rd ed., 2016), Alberts et al., Molecular Biology of the Cell (6th ed., 2014), or Lodish et al., Molecular Cell Biology (8th edition, 2016).
MW 1:45pm-3pm

CBIO 603a / MCDB 603a, Seminar in Molecular Cell BiologyMegan King

A graduate-level seminar in modern cell biology. The class is devoted to the reading and critical evaluation of classical and current papers. The topics are coordinated with the CBIO 602 lecture schedule. Thus, concurrent enrollment in CBIO 602 is required.
Th 9am-11am

CBIO 604b / PTB 604b, Physiologic Function and Cellular Structure of Organ SystemsAgnes Vignery

Introduction to the organization and function of cells within complex multicellular systems as encountered in the human body. Covers major tissues and organs as well as the cardiovascular, immune, and nervous systems, with special emphasis on the molecular and cellular bases of developmental processes and human diseases. Lectures supplemented by electronic-based tutorials on the histology of tissues and organs.
TTh 9:30am-11am

CBIO 606b, Advanced Topics in Cell BiologyXiaolei Su

This seminar course, which meets once weekly, covers advanced topics in cell biology. Each topic is spread over two or three sessions, which start with an introductory overview and are followed by a discussion of key papers led by an expert in the field.
T 4pm-6pm

CBIO 655a or b / GENE 655a or b, Stem Cells: Biology and ApplicationIn-Hyun Park

This course is designed for first-year or second-year students to learn the fundamentals of stem cell biology and to gain familiarity with current research in the field. The course is presented in a lecture and discussion format based on primary literature. Topics include stem cell concepts, methodologies for stem cell research, embryonic stem cells, adult stem cells, cloning and stem cell reprogramming, and clinical applications of stem cell research. Prerequisites: undergraduate-level cell biology, molecular biology, and genetics.
HTBA

CBIO 701b, Illuminating Cellular FunctionDerek Toomre

The focus of the course is on the technical treatment of light microscopy and its applications. The course provides biology and bioengineering students with the knowledge and skills necessary to design and undertake advanced light microscopy experiments. It covers conceptual elements of fluorescence microscopy imaging and analysis (without going too heavily into the theory and math); new advances in super-resolution modalities; biological applications; and hands-on practical work. Enrollment limited to fifteen.
MW 1:30pm-4pm

CBIO 901b / GENE 901b / MCDB 901b, Research Skills and Ethics IIChenxiang Lin

This course consists of a weekly seminar that covers ethics, writing, and research methods in cellular and molecular biology as well as student presentations (“rotation talks”) of work completed in the third laboratory rotation.
HTBA

CBIO 903a or b, Reading Course in Cell BiologyStaff

Independent study of specific topics in cell biology through directed reading of the literature under faculty supervision. Student may choose any topic and any Yale faculty who agree to participate. Subject to approval by the cell biology DGS. Open to cell biology students and to students in other departments with approval from their respective DGS.
HTBA

CBIO 911a / GENE 911a / MCDB 911a, First Laboratory RotationChenxiang Lin

First laboratory rotation for Molecular Cell Biology, Genetics, and Development (MCGD) and Plant Molecular Biology (PMB) track students.
HTBA

CBIO 912a / GENE 912a / MCDB 912a, Second Laboratory RotationStaff

Second laboratory rotation for Molecular Cell Biology, Genetics, and Development (MCGD) and Plant Molecular Biology (PMB) track students.
HTBA

CBIO 913b / GENE 913b / MCDB 913b, Third Laboratory RotationShirin Bahmanyar

Third laboratory rotation for Molecular Cell Biology, Genetics, and Development (MCGD) and Plant Molecular Biology (PMB) track students.
HTBA