Sterling Chemistry Laboratory, 203.432.3913
Gary Brudvig (1 SCL, 203.432.3912, firstname.lastname@example.org)
Director of Graduate Studies
Elsa Yan (email@example.com)
Professors Victor Batista, Gary Brudvig, Robert Crabtree, Craig Crews,* R. James Cross, Jr. (Emeritus), Jonathan Ellman, John Faller (Emeritus), Nilay Hazari, Seth Herzon, Patrick Holland, Francesco Iachello,* Mark Johnson, William Jorgensen, J. Patrick Loria, James Mayer, J. Michael McBride (Emeritus), Scott Miller, Peter Moore (Emeritus), Anna Pyle,* Lynne Regan,* James Rothman,* Martin Saunders, Alanna Schepartz, Charles Schmuttenmaer, Dieter Söll,* David Spiegel, Thomas Steitz,* Scott Strobel,* John Tully (Emeritus), Patrick Vaccaro, Elsa Yan, Frederick Ziegler (Emeritus), Kurt Zilm
Assistant Professors Richard Baxter, Jason Crawford, Ziad Ganim, Timothy Newhouse, Sarah Slavoff, Hailiang Wang
Lecturers Paul Anastas, Christine DiMeglio, Narasimhan Ganapathi, Jonathan Parr
A secondary appointment with primary affiliation in another department.
Fields of Study
Fields include bio-inorganic chemistry, bio-organic chemistry, biophysical chemistry, chemical biology, chemical physics, inorganic chemistry, materials chemistry, organic chemistry, physical chemistry, physical-inorganic chemistry, physical-organic chemistry, synthetic-organic chemistry, and theoretical chemistry.
Special Admissions Requirements
Applicants are expected to have completed or be completing a standard undergraduate chemistry major including a year of elementary organic chemistry with laboratory, and a year of elementary physical chemistry. Other majors are acceptable if the above requirements are met. The GRE General Test is required. The GRE Subject Test is strongly recommended though not required. Students whose native language is not English are required to take the Test of English as a Foreign Language (TOEFL).
Special Requirements for the Ph.D. Degree
A foreign language is not required. Three term courses are required in each of the first two terms of residence. Courses are chosen according to the student’s background and research area. To be admitted to candidacy a student must (1) receive at least two term grades of Honors, exclusive of those for research; (2) pass one oral examination (preparative chemistry students) or two oral examinations (physical chemistry students) by the end of the second year of study; and (3) submit a thesis prospectus no later than the end of the third year of study. Remaining degree requirements include completing a formal proposal (inorganic, organic, and chemical biology students), a written thesis describing the research, and an oral defense of the thesis. The ability to communicate scientific knowledge to others outside the specialized area is crucial to any career in chemistry. Therefore, all students are required to teach a minimum of two terms at a TF level 20. Students may be required by their advisers to teach in additional terms, but would not be required to teach more than five terms over their first five years. All students are required to take CHEM 590, Ethical Conduct and Scientific Research, in the fall term of their first year of study.
M.S. (en route to the Ph.D.) A student must pass at least five graduate-level term courses in the Chemistry department exclusive of seminars and research. In addition, an overall average (exclusive of seminars and research) of High Pass must be maintained in all courses. One full year of residence is required.
Program materials are available upon request to the Director of Graduate Studies, Department of Chemistry, Yale University, PO Box 208107, New Haven CT 06520-8107.
CHEM 505a, Alternative Energy Gary Brudvig
Design principles for molecular components of alternative energy devices. Climate change and our alternative energy future. Light energy conversion, energy transfer, and charge separation in photosynthesis. Dioxygen evolution in photosystem II. Biofuels: bioethanol, biodiesel, hydrogenase. Interaction of light with semiconductors. Fast spectroscopy to probe interfacial electron transfer. Computational design and characterization. Solar cells for electricity, photo-catalysis, biomimetic water oxidation. Hydrogen economy. Team-taught.
CHEM 518a, Advanced Organic Chemistry William Jorgensen
Concise overview of structure, properties, thermodynamics, kinetics, reactions, and intermolecular interactions for organic molecular systems.
CHEM 521a, Chemical Biology Jason Crawford and Alanna Schepartz
A one-term introduction to the origins and emerging frontiers of chemical biology. Discussion of the key molecular building blocks of biological systems and the history of macromolecular research in chemistry.
CHEM 525b, Spectroscopic Methods of Structure Determination Martin Saunders
The background and use of spectroscopic methods emphasizing NMR in organic chemistry. The course includes the use of programs for simulating spin-spin coupling and rapid rearrangement reactions in NMR. All methods commonly used by organic chemists for determining molecular structures of species in solution, in the gas phase, and in solids are included.
CHEM 528a, Natural Products Synthesis Seth Herzon
Survey of natural products syntheses, with an emphasis on those that contain unique strategies, transformations, or reagents. Key transformations are introduced in the context of various syntheses. Retrosynthetic analysis and synthetic planning are discussed.
CHEM 529b, Special Topics in Chemical Biology Timothy Newhouse and David Spiegel
Current topics at the interface of chemistry, biology, and medicine with an emphasis on synthetic biology approaches.
CHEM 530b, Statistical Methods and Thermodynamics Victor Batista
The fundamentals of statistical mechanics developed and used to elucidate gas phase and condensed phase behavior, as well as to establish a microscopic derivation of the postulates of thermodynamics. Topics include ensembles; Fermi, Bose, and Boltzmann statistics; density matrices; mean field theories; phase transitions; chemical reaction dynamics; time-correlation functions; Monte Carlo and molecular dynamics simulations.
CHEM 531b, Special Topics in Organic Chemistry Jonathan Ellman and Seth Herzon
Current topics in organic chemistry.
CHEM 537a, Chemistry of Isotopes Martin Saunders
Advanced applications of isotopes to chemical problems and the theory associated with them, including kinetic and equilibrium isotope effects, tracer applications, and dating.
CHEM 540a, Molecules and Radiation I Kurt Zilm
An integrated treatment of quantum mechanics and modern spectroscopy. Basic wave and matrix mechanics, perturbation theory, angular momentum, group theory, time-dependent quantum mechanics, selection rules, coherent evolution in two-level systems, line shapes, and NMR spectroscopy.
CHEM 542b, Molecules and Radiation II Mark Johnson
An extension of the material covered in CHEM 540 to atomic and molecular spectroscopy, including rotational, vibrational, and electronic spectroscopy, as well as an introduction to laser spectroscopy.
CHEM 548a, Nuclear Magnetic Resonance in Liquids J. Patrick Loria
A theoretical treatment of solution NMR spectroscopy with emphasis on applications to proteins and biological macromolecules. This includes classical and quantum mechanical descriptions of NMR, product operator formalism, multidimensional NMR, phase cycling, gradient selection, relaxation phenomena, and protein resonance assignments.
CHEM 552a, Organometallic Chemistry Robert Crabtree
A survey of the organometallic chemistry of the transition elements and of homogeneous catalysis.
CHEM 553b, Small Molecule X-ray Crystallography Patrick Holland and Brandon Mercado
This course provides an introduction to small molecule crystallography. It covers both theoretical and applied concepts and includes hands-on experience on how to solve and refine the structure of small molecules.
CHEM 554b, Bio-Inorganic Chemistry Patrick Holland
An advanced introduction to biological inorganic chemistry. Important topics in metalloprotein chemistry are illustrated. Objective is to define and understand function in terms of structure. Topics include catalysis with and without electron transfer, and carbon, oxygen, and nitrogen metabolism.
CHEM 556b, Biochemical Rates and Mechanisms J. Patrick Loria
An advanced treatment of enzymology. Topics include transition state theory and derivation of steady-state and pre-steady-state rate equations. The role of entropy and enthalpy in accelerating chemical reactions is considered, along with modern methods for the study of enzyme chemistry. These topics are supplemented with in-depth analysis of the primary literature.
CHEM 557b, Modern Coordination Chemistry Nilay Hazari
The principles of modern inorganic chemistry. Main group and transition element chemistry: reactions, bonding, structure, and spectra.
CHEM 559b, Biophysics Elsa Yan
A discussion of applications of quantitative biophysical methods to biomolecules. Emphasis is placed on interpreting experimental data obtained by various biophysical methods to gain structural and dynamic information to address biological questions at the molecular level. Topics include mainly spectroscopic methods, such as Raman, single-molecule, fluorescence, FTIR, chiroptical, and higher-order optical spectroscopies. Discussions focus on current and classic studies reported in the literature.
CHEM 560La, Advanced Instrumentation Laboratory I Mark Johnson
A laboratory course introducing physical chemistry tools used in the experimental and theoretical investigation of large and small molecules. Modules include electronics, vacuum technology, optical spectroscopy and lasers, and computer programming.
CHEM 562La or b, Laboratory in Instrument Design and the Mechanical Arts Kurt Zilm and David Johnson
Familiarization with modern machine shop practices and techniques. Use of basic metalworking machinery and instruction in techniques of precision measurement and properties of commonly used metals, alloys, and plastics.
CHEM 564La or b, Advanced Mechanical Instrumentation Kurt Zilm and David Johnson
A course geared for both the arts and sciences that goes beyond the basic introductory shop courses, offering an in-depth foundation study utilizing hands-on instructional techniques that must be learned from experience. Prerequisite: CHEM 562L.
CHEM 565La or b, Introduction to Glass Blowing Patrick Vaccaro and Daryl Smith
The course provides a basic introduction to the fabrication of scientific apparatus from glass. Topics covered include laboratory setup, the fundamental skills and techniques of glass blowing, the operation of glass fabrication equipment, and requisite safety procedures.
CHEM 570a, Quantum Chemistry Victor Batista
The elements of quantum mechanics developed and illustrated with applications in chemistry and chemical physics.
CHEM 590a, Ethical Conduct and Scientific Research Jonathan Parr
A survey of ethical questions relevant to the conduct of research in the sciences with particular emphasis on chemistry. A variety of issues, including plagiarism, the falsification of data, and financial malfeasance, are discussed, using as examples recent cases of misconduct by scientists. Enrollment is restricted to graduate students in chemistry. 0 Course cr
CHEM 600a or b, Research Seminars Staff
Presentation of a student's research results to the student's adviser and fellow research group members. Extensive discussion and literature review are normally a part of the series.
CHEM 700a or b, Laboratory Rotation for First-Year Biophysical and Chemical Biology Graduate Students Staff
CHEM 720a and CHEM 721b, Current Topics in Organic Chemistry Seth Herzon
A seminar series based on invited speakers in the general area of organic chemistry.
CHEM 730a and CHEM 731b, Molecular Science Seminar Mark Johnson
A seminar series based on invited speakers in the areas of physical, inorganic, and biological chemistry.
CHEM 740a and CHEM 741b, Seminar in Chemical Biology Jonathan Ellman
CHEM 750a and CHEM 751b, Biophysical Chemistry Seminar J. Patrick Loria
CHEM 760a and CHEM 761b, Seminar in Inorganic Chemistry Nilay Hazari
CHEM 990a or b, Research Staff
Individual research for Ph.D. degree candidates in the Department of Chemistry, under the direct supervision of one or more faculty members.